About HERMES
About HERMES
HERMES enables the topological discrimination of molecular models of nucleic acids derived by theoretical methods. The calculations are based on prediction of magnetic field-induced residual dipolar coupling (fiRDCs), based on the molecule's 3D shape and the assessment of the underlying molecular alignment tensor.
Statistical comparisons of predicted fiRDCs with experimentally measured serve
(i) validation of structural model derived by theoretical methods
(ii) low-resolution identification inside the complex intracellular environment of living cells.
The software provides four options based on the intended application:
1. Prediction of fiRDCs
2. Assessment of experimentally acquired fiRDCs, by means of comparing them with predicted fiRDCs
3. Assessment of proposed structural models, based on the assessment of experimental fiRDCs
4. Relative Domain Orientation
